Journal Club July 11, 2006

J Clin Invest. 2006 Jan;116(1):80-9.

Early G2/M checkpoint failure as a molecular mechanism underlying etoposide-induced chromosomal aberrations.

Nakada S, Katsuki Y, Imoto I, Yokoyama T, Nagasawa M, Inazawa J, Mizutani S.

J Clin Invest. 2006 Jan;116(1):182-92.

Aberrant maturation of mutant perforin underlies the clinical diversity of hemophagocytic lymphohistiocytosis.

Risma KA, Frayer RW, Filipovich AH, Sumegi J.

J Clin Invest. 2006 Mar;116(3):652-62.

A homing mechanism for bone marrow-derived progenitor cell recruitment to the neovasculature.

Jin H, Aiyer A, Su J, Borgstrom P, Stupack D, Friedlander M, Varner J.

J Clin Invest. 2006 Apr;116(4):984-95.

Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis.

Thimmulappa RK, Lee H, Rangasamy T, Reddy SP, Yamamoto M, Kensler TW, Biswal S.

J Clin Invest. 2006 May;116(5):1317-26.

Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis.

Chen Y, Langrish CL, McKenzie B, Joyce-Shaikh B, Stumhofer JS, McClanahan T, Blumenschein W, Churakovsa T, Low J, Presta L, Hunter CA, Kastelein RA, Cua DJ

J Clin Invest. 2006 Jun;116(6):1642-50.

Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors.

Netea MG, Gow NA, Munro CA, Bates S, Collins C, Ferwerda G, Hobson RP, Bertram G, Hughes HB, Jansen T, Jacobs L, Buurman ET, Gijzen K, Williams DL, Torensma R, McKinnon A, MacCallum DM, Odds FC, Van der Meer JW, Brown AJ, Kullberg BJ.

J Clin Invest. 2006 May;116(5):1195-201.

The stem cell niches in bone.

Yin T, Li L.

J Exp Med. 2006 Jan 23;203(1):27-33.

The fate of human Langerhans cells in hematopoietic stem cell transplantation.

Collin MP, Hart DN, Jackson GH, Cook G, Cavet J, Mackinnon S, Middleton PG, Dickinson AM.

J Exp Med. 2006 Jan 23;203(1):73-85.

Purified hematopoietic stem cell engraftment of rare niches corrects severe lymphoid deficiencies without host conditioning.

Bhattacharya D, Rossi DJ, Bryder D, Weissman IL.

J Exp Med. 2006 Jan 23;203(1):87-97.

G-CSF/SCF reduces inducible arrhythmias in the infarcted heart potentially via increased connexin43 expression and arteriogenesis.

Kuhlmann MT, Kirchhof P, Klocke R, Hasib L, Stypmann J, Fabritz L, Stelljes M, Tian W, Zwiener M, Mueller M, Kienast J, Breithardt G, Nikol S.

J Exp Med. 2006 Jan 23;203(1):227-38.

Activation of the Flt3 signal transduction cascade rescues and enhances type I interferon-producing and dendritic cell development.

Onai N, Obata-Onai A, Tussiwand R, Lanzavecchia A, Manz MG.

J Exp Med. 2006 Feb 20;203(2):371-81

Block of C/EBP alpha function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations.

Radomska HS, Basseres DS, Zheng R, Zhang P, Dayaram T, Yamamoto Y, Sternberg DW, Lokker N, Giese NA, Bohlander SK, Schnittger S, Delmotte MH, Davis RJ, Small D, Hiddemann W, Gilliland DG, Tenen DG.

J Exp Med. 2006 May 15;203(5):1259-71.

Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy.

Reits EA, Hodge JW, Herberts CA, Groothuis TA, Chakraborty M, Wansley EK, Camphausen K, Luiten RM, de Ru AH, Neijssen J, Griekspoor A, Mesman E, Verreck FA, Spits H, Schlom J, van Veelen P, Neefjes JJ.

Blood. 2006 Feb 1;107(3):898-903

EFA (9-beta-D-erythrofuranosyladenine) is an effective salvage agent for methylthioadenosine phosphorylase-selective therapy of T-cell acute lymphoblastic leukemia with L-alanosine.

Batova A, Cottam H, Yu J, Diccianni MB, Carrera CJ, Yu AL.


Blood. 2006 Feb 1;107(3):1116-23

Clinical significance of minimal residual disease quantification in adult patients with standard-risk acute lymphoblastic leukemia.

Bruggemann M, Raff T, Flohr T, Gokbuget N, Nakao M, Droese J, Luschen S, Pott C, Ritgen M, Scheuring U, Horst HA, Thiel E, Hoelzer D, Bartram CR, Kneba M; German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia.

Blood. 2006 Feb 1;107(3):1220-6.

HLA-DPB1 matching status has significant implications for recipients of unrelated donor stem cell transplants.

Shaw BE, Marsh SG, Mayor NP, Russell NH, Madrigal JA.

Blood. 2006 Feb 15;107(4):1308-14.

Minor population of CD55-CD59- blood cells predicts response to immunosuppressive therapy and prognosis in patients with aplastic anemia.

Sugimori C, Chuhjo T, Feng X, Yamazaki H, Takami A, Teramura M, Mizoguchi H, Omine M, Nakao S.

Blood. 2006 Feb 15;107(4):1315-24.

Randomized use of cyclosporin A (CsA) to modulate P-glycoprotein in children with AML in remission: Pediatric Oncology Group Study 9421.

Becton D, Dahl GV, Ravindranath Y, Chang MN, Behm FG, Raimondi SC, Head DR, Stine KC, Lacayo NJ, Sikic BI, Arceci RJ, Weinstein H; Pediatric Oncology Group.

Blood. 2006 Feb 15;107(4):1712-6.

Impact of posttransplantation G-CSF on outcomes of allogeneic hematopoietic stem cell transplantation.

Khoury HJ, Loberiza FR Jr, Ringden O, Barrett AJ, Bolwell BJ, Cahn JY, Champlin RE, Gale RP, Hale GA, Urbano-Ispizua A, Martino R, McCarthy PL, Tiberghien P, Verdonck LF, Horowitz MM.

Exp Hematol. 2006 Jan;34(1):107-14.

Evidence that donor intrinsic response to G-CSF is the best predictor of acute graft-vs-host disease following allogeneic peripheral blood stem cell transplantation.

Dhedin N, Chamakhi I, Perreault C, Roy DC, Sauvageau G, Ducruet T, Busque L, Fish D, Belanger R, Roy J.

Exp Hematol. 2006 Mar;34(3):389-96.

The development of autoantibodies after allogeneic stem cell transplantation is related with chronic graft-vs-host disease and immune recovery.

Patriarca F, Skert C, Sperotto A, Zaja F, Falleti E, Mestroni R, Kikic F, Calistri E, Fili C, Geromin A, Cerno M, Fanin R.

Exp Hematol. 2006 Apr;34(4):453-62.

Epigenetic heterochromatin markers distinguish terminally differentiated leukocytes from incompletely differentiated leukemia cells in human blood.

Popova EY, Claxton DF, Lukasova E, Bird PI, Grigoryev SA.

Exp Hematol. 2006 May;34(5):610-21.

Leukemia-stimulated bone marrow endothelium promotes leukemia cell survival.

Veiga JP, Costa LF, Sallan SE, Nadler LM, Cardoso AA.

Exp Hematol. 2006 May;34(5):642-53.

Human herpesvirus 6 impairs differentiation of monocytes to dendritic cells.

Niiya H, Lei J, Guo Y, Azuma T, Yakushijin Y, Sakai I, Hato T, Tohyama M, Hashimoto K, Yasukawa M.