Journal Club June 13, 2006

Nature. 2006 May 11;441(7090):179-85.

A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function.

Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A.

Nat Med. 2006 Apr;12(4):446-51.

Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells.

Ito K, Hirao A, Arai F, Takubo K, Matsuoka S, Miyamoto K, Ohmura M, Naka K, Hosokawa K, Ikeda Y, Suda T.

Nature. 2006 Mar 30;440(7084):702-6.

Oncogenic activity of Cdc6 through repression of the INK4/ARF locus.

Gonzalez S, Klatt P, Delgado S, Conde E, Lopez-Rios F, Sanchez-Cespedes M, Mendez J, Antequera F, Serrano M.

Nat Genet. 2006 May;38(5):540-549.

Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band.

Frigola J, Song J, Stirzaker C, Hinshelwood RA, Peinado MA, Clark SJ.

Nat Immunol. 2006 May;7(5):466-74.

Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance.

Kallies A, Hawkins ED, Belz GT, Metcalf D, Hommel M, Corcoran LM, Hodgkin PD, Nutt SL.

Nat Immunol. 2006 Apr;7(4):382-91.

Early hematopoietic lineage restrictions directed by Ikaros.

Yoshida T, Yao-Ming Ng S, Zuniga-Pflucker JC, Georgopoulos K.

Leukemia. 2006 Mar;20(3):451-7.

Monitoring minimal residual disease by quantification of genomic chromosomal breakpoint sequences in acute leukemias with MLL aberrations.

Burmeister T, Marschalek R, Schneider B, Meyer C, Gokbuget N, Schwartz S, Hoelzer D, Thiel E.

Leukemia. 2006 May;20(5):820-6.

Unsupervised proteome analysis of human leukaemia cells identifies the Valosin-containing protein as a putative marker for glucocorticoid resistance.

Lauten M, Schrauder A, Kardinal C, Harbott J, Welte K, Schlegelberger B, Schrappe M, von Neuhoff N.

Blood. 2006 Mar 1;107(5):1791-9.

KIT-D816 mutations in AML1-ETO-positive AML are associated with impaired event-free and overall survival.

Schnittger S, Kohl TM, Haferlach T, Kern W, Hiddemann W, Spiekermann K, Schoch C.

Blood. 2006 Mar 1;107(5):1806-9.

KIT mutations, and not FLT3 internal tandem duplication, are strongly associated with a poor prognosis in pediatric acute myeloid leukemia with t(8;21): a study of the Japanese Childhood AML Cooperative Study Group.

Shimada A, Taki T, Tabuchi K, Tawa A, Horibe K, Tsuchida M, Hanada R, Tsukimoto I, Hayashi Y.

Blood. 2006 Mar 1;107(5):1878-87.

Reconstitution of the functional human hematopoietic microenvironment derived from human mesenchymal stem cells in the murine bone marrow compartment.

Muguruma Y, Yahata T, Miyatake H, Sato T, Uno T, Itoh J, Kato S, Ito M, Hotta T, Ando K.

Blood. 2006 Mar 1;107(5):1970-3.

Human leukocyte antigen (HLA) DR15 is associated with reduced incidence of acute GVHD in HLA-matched allogeneic transplantation but does not impact chronic GVHD incidence.

Battiwalla M, Hahn T, Radovic M, Roy H, Wahab A, Duman E, Bajwa R, Padmanabhan S, Becker J, Barrett AJ, McCarthy PL Jr.

Blood. 2006 Mar 1;107(5):2061-9.

Reconstitution Identification of glucocorticoid-response genes in children with acute lymphoblastic leukemia.

Schmidt S, Rainer J, Riml S, Ploner C, Jesacher S, Achmuller C, Presul E, Skvortsov S, Crazzolara R, Fiegl M, Raivio T, Janne OA, Geley S, Meister B, Kofler R.

Blood. 2006 Mar 1;107(5):2162-9.

Selection based on CD133 and high aldehyde dehydrogenase activity isolates long-term reconstituting human hematopoietic stem cells.

Hess DA, Wirthlin L, Craft TP, Herrbrich PE, Hohm SA, Lahey R, Eades WC, Creer MH, Nolta JA.