Pediatric Hematology/Oncology (AREKEN) Osaka Univ Grad School Med

We are treating children with cancer and hematological disorder at Osaka University Hospital, Japan.
Contact us at areken@ped.med.osaka-u.ac.jp

Saturday, April 15, 2006

Morning Seminar Vol 2 April 2005-June 2005

Basic knowledge of chemotherapy 1

MLD 21

Mutation in TERT, the gene for telomerase RT, in AA (Yamaguchi, N Engl J Med 2005) 22

8th Infant Leukemia Seminar (1) 23

Chemotherapy-induced nausea and vomiting: current and new standards in the antiemetic prophylaxis and treatment (Jordan, Eur J Cancer 2005) 26

Juvenile granulosa cell tumor 29

HDC with autologous stem cell rescue for children with highrisk and recurrent medulloblastoma and supratentorial PNET (Perez-Martinez, J Neurooncol 2005) 33

8th Infant Leukemia Seminar (2) 36

Antileukemic and long-term effects of two regimens with or without TBI in allogeneic BMT for childhood ALL (Dai, BMT 2004) 38

Taxane chemotherapeutic drugs 41

Efficacy of topotecan and cyclophosphamide given in a phase II window trial in children with newly diagnosed metastatic RMS: A COG study (Demirer, JCO 2004) 46

Arrythmia 48

Cardiac function 52

Serial evaluation of academic and behavioral outcome after treatment cranial radiation in childhood (Mabott, JCO 2005) 54

Hypercalcemia and malignancy 56

Dose intensity and the toxicity and efficacy of allogeneic hematopoietic transplantation (Appelbaum, Leukemia 2005) 63

Thrombotic microangiophathy with diarrhea 67

GVT effects after allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning (Baron, JCO 2005) 75

Congenital pure red cell aplasia 83

Use of Oseltamivir to control influenza complications after BMT (Machado, BMT 2004) 85

Vascular endothelial function in survivors of childhood cancer 90

Kawasaki Disease 98

Final adult height of patients who received hematopoietic cell transplantation in childhood (Sanders, Blood 2005) 100

Analysis of 96 patients with advanced ovarian carcinoma treated with HDC and ASCT (Donato, BMT 2004)
High-dose topotecan, melphalan, and cyclophosphamide (TMC) with stem cell support: a new regimen for the treatment of advanced ovarian cancer (Donato, Gynecol Oncol 2001)

A phase I and pharmacodynamic study of fludarabine, carboplatin, and topotecan in patients with relapsed, refractory, or high-risk acute leukemia (Cooper, Clin Cancer Res 2004) 104

Symposium for Fludara’s 5th anniversary
Non-myeloablative SCT 108

DNA topoisomerase II in therapy-related APL (N Engl J Med 2005) 110

The Japan Pediatric Society
108th Annual Meeting (2005.4) Part 1 115

Reduction from seven to five cycles of intensive induction chemotherapy in children with high-risk NB (Kushner, JCO 2004) 118

The effect of first-line imatinib interim therapy on the outcome of allogeneic SCT in adults with newly diagnosed Philadelphia chromosome-positive ALL (Lee, Blood 2005) 120

The Japan Pediatric Society
108th Annual Meeting (2005.4) Part 2 122

Accidental busulfan overdose during conditioning for SCT (Junke, BMT 2005) 125

J Jpn Pediatr 19(2), 2005 129

Somnolence syndrome 136

Allogeneic hematopoietic cell transplantation for infants with ALL (Sanders, Blood 2005) 137

JACLS(MLL-98) 141

RIST #1 143

Genetic subtypes of FHL: correlations with clinical features and CTL/NK cell functions (Blood 2005) 152

RIST #2 155

Treatment of early childhood medulloblastoma by postoperative chemotherapy alone (Rutkowski, N Engl J Med 2005) 159

Rituximab plus short-duration chemotherapy as first-line treatment for follicular NHL: a phase II trial of the Minnie Pearl Cancer Research Network (Hainswroth, JCO 2005) 163

HDF 167

Expression of IL-10 splicing variants is a positive prognostic feature in relapsed ALL (Wu, JCO 2005) 170

Medulloblastoma in the second decade of life: a specific group with respect to toxicity and management (Tabori, Cancer 2005) 173

Postoperative chemotherapy in advanced ovarian granulosa cell tumors (Al-Badawi, Int J Gynecol Cancer 2002) 176

Difference in time to positivity is useful for the diagnosis of catheter-related bloodstream infection in hematopoietic SCT recipients (Abdelkefi, BMT 2005) 178

Unrelated donor SCT compared with chemotherapy for children with ALL in a second remission: a matched-pair analysis (Borgmann, Blood 2003) 182

Tacrolimus-related encephalopathy following allogeneic SCT in children (Kanekiyo, Int J Hematol 2005) 186

Tacrolimus-associated posterior reversible encephalopathy syndrome after allogeneic hematopoietic SCT (Wong, Br J Haematol 2003) 188

Meta-analysis: the effect of steroids on survival and shock during sepsis depends on the dose (Minneci, Ann Intern Med 2004) 192

Early responses to chemotherapy of normal and malignant hematologic cells are prognostic in children with ALL (Stephan, JCO 2005) 196

A prospective randomized study of clinical and economic consequences of using G-CSF following autologous PBPC transplantation in children (Gonzalez-Vincent, BMT 2004) 200

The risk of developing second cancers among survivors of childhood soft tissue sarcoma (Cohen, Cancer 2005) 206

Transplantation of 2 partially HLA-matched umbilical cord blood units with malignant disease (The 6th Nagoya International Blood and Marrow Transplantation Symposium: 21-22 May, 2005) 208

Umbilical CBT in Europe: An Eurocord survey (The 6th Nagoya International Blood and Marrow Transplantation Symposium: 21-22 May, 2005) 216

Sensitivity to L-Asp is not associated with expression levels of AS in t(12;21)+ pediatric ALL (Wendy, Blood 2003) 222

AS expression is linked with L-Asp resistance in TEL-AML1-negative but not TEL-AML1-positive pediatric ALL (Wendy, Blood 2005) 224

Duration of immunosuppressive treatment for cGVHD (Stewart, Blood 2004) 226

CBTs from unrelated donors in patients with Hurler’s syndrome (Staba, N Engl J Med 2004) 230

Transplantation of umbilical-cord blood in babies with infantile Krabbe’s disease (Escolar, N Engl J Med 2005) 232

Effect of SCT on seven cases of leucodystrophy 237

J Jpn Pediatr 109 (5), 2005 242

High-dose chemotherapy followed by locoregional irradiation improves the outcome of patients with international NB staging system stage II and III NB with MYCN amplification (Laprie, Cancer 2004) 245

10th Pediatric MDS Study group (2005.6.5 Tokyo) 249

Ovarian granulosa cell tumors in childhood (Marras-Salmio, Pediatr Hematol Oncol 2002) 257

Late mortality in survivors of autologous hematopoietic-cell transplantation: report from BMT survivor study (Bhatia, Blood 2005) 261

Results of treatment for NB 265

Reports on allogeneic SCT for pediatric solid tumor 267

Response to paclitaxel, topotecan, and topotecan-cyclophosphamide in children with untreated disseminated NB treated in an upfront Phase II investigation window: a Pediatric Oncology Group study (JCO 2004) 268

12th Pediatric AA Study group (2005.6.4 Tokyo) 272

HLA typing of JMDP 277

Aplastic anemia (Brodsky, Lancet 2005) 278

Life-threatening neurological complications after BMT in children (Uckan, BMT 2005) 284

PFAPA (9th Osaka Pediatric Immunology Study Group 2005.6.9) 286

Nephroprotection by theophylline in patients with cisplatin chemotherapy: a randomized, single-blinded, placebo-controlled trial (Benoehr, J Am Soc Nephrol 2005) 294

Use of rituximab to treat refractory Diamond-Blackfan anemia (Morimoto, Eur J Hematol 2005) 297

Steroids prevent engraftment syndrome after autologous hematopoietic SCT without increasing the risk of infection (Mossad, BMT 2005) 300

Engraftment syndrome after autologous peripheral blood progenitor cell transplantation in pediatric patients: a prospective evaluation of risk factors and outcome (Gonzalez-Vincent, BMT 2004) 301

Autologous PBSCT with induction of autologous GVHD in AML (Park, BMT 2003) 303

CIAS1 mutation (CINCA, FCAS, Muckle-Wells syndrome)
304

Asthma as a consequence of BMT (Rietz, Chest 2002) 310

Immune reconstitution after childhood ALL is most severely affected in the high risk group (Torben, Pediatr Blood Cancer 2005) 312

Efficacy of topotecan and cyclophosphamide given in a phase II window trial in children with newly diagnosed metastatic RMS: a children’s oncology group study (Walterhouse, JCO 2004) 316

Micafungin versus fluconazole for prophylaxis against fungal infections during neutropenia in patients undergoing hematopoietic SCT (van Burik, Clin Infect Disease 2004) 320

After major ABO-mismatched allogeneic hematopoietic progenitor cell transplantation, erythroid engraftment occurs later in patients with donor blood group A than donor blood group B (Shetelig, Transfusion 2005) 322

Exacerbating factor of allergy after pediatric liver transplantation
325

Treatment of early childhood medulloblastoma by postoperative chemotherapy alone (Rutkowski, N Engl J Med 2005) 332

Neuropsychological performance and QOL of 10 year survivors of childhood medulloblastoma (Maddrey, J Neurooncol 2005) 335

The risk of developing second cancers among survivors of childhood soft tissue sarcoma (Cohen, Cancer 2005) 337

Long term follow-up after splenectomy peformed for ITP (Schwartz, Am J Hematol 2003) 340

Alveolar soft part sarcoma 343